Neural Stem Cells for Brain and Spinal Cord Repair

Neural Stem Cells for Brain and Spinal Cord Repair

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Active neuroscientists survey NSCs as potential tools for central nervous system and spinal cord repair by explaining their clinically significant fundamental properties, manipulations, and potential therapeutic paradigms. Their discussion of the fundamental biology of NSCs illustrates the signaling pathways that regulate stem cell division and differentiation, and defines the methods of NSC expansion and propagation, neuromorphogenesis, the factors determining cell fate both in vitro and in situ, and the induction of self-reparative processes within the brain. They also present strategies that may lead to fruitful clinical applications in the near future. These range from the replacement of degenerated, dysfunctional, or maldeveloped cells to the provision of factors that may protect, correct, recruit, promote self-repair, or mediate the connectivity of host cells.Existing data support the potential of bone marrow cells to promote the regeneration of damaged nerves. Implantation of damaged nerves into the region of a subsequent sciatic nerve crush in rats enhances regeneration of the sensory nerves, anbsp;...

Title:Neural Stem Cells for Brain and Spinal Cord Repair
Author: Tanja Zigova
Publisher:Springer Science & Business Media - 2002-11-05

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